![]() If this is then injected into a person, it will not work properly, the body will not make the spike protein and there will be no immune response. If left out for too long before being injected, the vaccine gets too warm, and this begins the natural decay of the mRNA. One proven method is extremely cold temperatures, which stops all movement and reactions and prevents any form of decomposition of the mRNA. However, the vaccine must be administered at room temperature because the mRNA needs to be mobile. There are not many proven ways of ensuring long-term survival of the vaccine. This poses a significant problem when trying to get the mRNA vaccine into a human as under normal conditions it will break down and become useless. Pfizer's jab tells the body to create the coronavirus's unique spike protein, training the immune system to recognise and fight off future infection.īut, as a result of the natural rapid turnaround of mRNA's lifespan, it is, by nature, a short-lived molecule only ever intended to exist for a matter of hours. Messenger RNA is used by human cells to carry messages and give instructions. It is made from volatile genetic material known as mRNA, which is constantly under threat from being destroyed by other molecules in the environment.īioNTech packages the vaccine in dry-ice stuffed batches of 975 vials, each containing five doses, which must be stored at -70C to stop the mRNA being destroyed in transit or storage. The breakthrough jab - shown to be 95 per cent effective at blocking Covid-19 - was the first vaccine against the virus in the world to seal approval when Britain gave it the green light in December. The documents were leaked to the British Medical Journal (BMJ) following a cyber attack on the EU regulator in December. On the back of the find, EU officials filed two 'major objections' to Pfizer, along with a host of other quality control questions it wanted addressed, before it could approve the vaccine. Regulators in the EU and UK check every batch of the vaccine before allowing them to be used. It's unclear if similar quality issues were raised in the UK, where the Pfizer jab is one of two vaccines that has been rolled out to 23million Brits already. Pfizer claims the affected jabs were not rolled out on the continent. The cause of the poorer quality was unknown and the impact on safety and efficacy of the vaccine was 'yet to be defined', the email said. In an email dated November 23, a senior European Medicines Agency official warned of a 'significant difference' in the quality of the vaccines compared to jabs used in Pfizer's clinical trials. Scientists charged with checking the chemicals sent to the bloc for approval last year found doses were of a lower standard than the US drugmaker had promised. Major concerns were raised about the quality of early batches of Pfizer's coronavirus vaccine, leaked documents from the EU's medical regulator have revealed.
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